I'm looking for the longest running threads (a post with replies) with several hundred (or thousands) of reply posts that use the standard Drupal forums. I know there are thousands of posts categorized at "Post installation" on Drupal.org, but most of those "topics" end after 20 posts. An unscientific guesstimate is that 75% end after 2 or 3 responses.
This thread for Truly corporate Drupal sites is at 213 response, but that is more of an announce list than a conversation. Contrib modules version 5.x status has 88 responses, but again those are announcements.
I've seen much longer threads on other sites, using other software. I wondering how much the design of Drupal forums is impacting the length of these discussion. You could make the case that users move on to another topic more quickly, but I find that when search for a something Drupal related on Google, I'll find several "topics" created in the same "forum" that discuss the same issue weeks or months apart.
I think forums that use topic splitting condition users to keep posting to the same thread. If the thread changes topic for too long, a moderator can split the thread and the discussion continues.
Why do all projects pages on Drupal.org have links into one giant support forum? Wouldn't it make sense to give them each a project specific forum that also appeared in the general support forum? Then if a developer felt the post didn't really apply to their module, but was an issue for another module or the Drupal core the post could be moved. I don't think this is possible with the current forums... but it is possible with Issues.

Comments
You're right on with the
You're right on with the question about the support forum link. It's pretty silly to dump someone into a huge support forum where they'll get lost trying to find anything related to that module. It reminds me of the way osCommerce handles contribution support... it just has a single "contribution support" forum where each contribution (think... module, but with a lot of code hacking necessary to get it to work) has one monster thread that you're supposed to find support in. It sucks.
We've got a few long posts
We've got a few long posts on our forums - 450 and 550.
I think the main issue with long threads on drupal is that comment links don't work unless they're on the first page of the pager - so it's several clicks to find where you were in a discussion.
I had the same problem with
I had the same problem with new comments added to my uieforum thread. The moderators/admins decided to just lock the thread when I started asking about that :(
It's actually a very big problem with drupal in general, not just the forums