domains

I'm excited to begin working with this module. It has been quite the task to enable a module or change a permissions setting across 40 sites, having to log into each one or via update.php.

So my question is, how would this integrate into a collection of 30 - 40 established sites in a multisite configuration?
Is this something that needs to be implemented from stage 1?

I read the description of what the HM2 does but am still a little unclear how it handles modules.
Can I enable/disable modules via HM2?
Can I modify access controls across all domains and/or each domain via HM2?

ok so we have plenty of people who are able to do a multi site install of Drupal where they are the host and the developer, or don't have others working on the same site.  I have a situation where I have multipul users that should not have access to each others files and I don't want to have to create additional ftp accounts.

I am on a LAMP server and want to be able to offer my customers the option to have a 'one install to rule them all' set up, minimizing the time it takes to upgrade the system.  Drupal 5's overrides system works great for this.