Flash/Flex and Yahoo Pipes

I've been exploring a bit into Yahoo Pipes and came across this Flex Based Mashup of last.fm and Youtube. Having seen this, I'm thinking there are all sorts of possibilities for this type of integration (by those who know their way around these applications).

I'm curious to know what experiences others have had - if this type of functionally could integrate w/ services/Drupal - and if people would be interested in some collaborative building and/or learning.