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"Large" Multisite / Domainaccess Hosting & Deployment

We are running about 50 Drupal 7 Multisites + 1 Domainaccess Site with 10 Domains on a 2x 64GB 16 Core Cluster Nodes with Apache mod_php with apc and mysql stack.

The multisites are utilizing all the same codebase and just differ in usage of content and node types.
At the moment there are 3 mysqld running on the host.
We are thinking about splitting the 50 multisites in 2 halfs and run another mysqld for that.

One of our main problems is, that deployments with changes to many features could take several hours at the moment.

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