mysql performance

Hi all..
i'll develop my website project and i choose to use drupal 6.14.
this website is directory business like and have a large database.
it's have 600.000 for company records and about 9.000.000 for product listing records.
But I have questions and doubts to use drupal, can drupal handle it with a good performance?
And what should i do to make this site have a good performance and fast loading?
For search module will use fuzzy logic,Are any suggestions for that in fast query searching?

MySQL queries in my production environment are taking much longer than I would expect them too. The site in question is a fairly large Drupal site, with many modules installed (about 140). The webserver (Nginx) and database server (mysql) are hosted on separated machines, connected by a 100mbps LAN connection (hosted by Rackspace). Both machines are Dual Core AMD Opteron 2216HE 2.4 GHz with 4GB RAM and are running Red Hat Enterprise.

I have the exact same site running on my laptop for development. Obviously, on my laptop, the webserver and database server are on the same box.

It is well-known that many very useful queries that you create (on your own or via the Views module) are costly to execute because MySQL creates a temporary table and does a filesort. A common example is {node}.type='xxx' and {node}.status='yyy' order by {node_comment_statistics}.comment_count desc.

Another common example is sorting posts in reverse chron order of most recent comment timestamp, which the Views module implements as order by GREATEST({node}.changed, {node_comment_statistics}.last_comment_timestamp) DESC