The following blog post inspired me to start using Chrome Canary: http://jtaby.com/2012/04/23/modern-web-development-part-1.html and I haven’t looked back since. If you’re a developer that link has a ton of stuff that I can’t possibly remember about what you can do with the Canary edition of Chrome. As a designer, I primarily use it the same way I used Firebug: checking CSS and layout issues.
Since my primary coding environment is on a Mac, Firefox has progressively gotten slower and slower and slower to the point where I just wiped all traces of it from my system and reinstalled during the lull between presentations. For now it’s running faster without the years of cruft that have built up, but Chrome Canary has stolen my heart at the moment.