You might wanna check out Nodepal - A Drupal integration layer for Node.js developers
This is a module that allows the integration of a Drupal installation with a custom Node.js app. It provides an API so that Node.js developers can directly read and write in Drupal's repository, using constructs like node, user, permission, etc., without having to worry about the underlying implementation and setup of the Drupal installation.
Use Cases:
- You have a working Drupal installation, with users, content, etc. and would like to add real-time services like chat, etc. The usual Apache-PHP-MySQL setup might not the best suited for this kind of apps, so you can develop you app in Node.js and hook it up to your Drupal, using the Nodelpal integration layer.
- You want to build a new Node.js app, that has some notion of users, roles, permissions or content and would like to use Drupal's user, roles, permissions, content model and its great administrative interface, without having to build everything from scratch.
- You want to build a new Node.js app and combine it with Drupal because there is some Drupal module that you find useful. E.g. you can add a Drupal forum, a Blog, or expose some content as a Web Service, or search it with Apache Solr. There is a Drupal module for everything!
FAQ:
Q: Why not have a Drupal Module, directly serve JSON to Node.js?
A: Putting a PHP stack, between your data repository and Node.js might introduce a significant bottleneck. Nodepal is based on the idea that Node.js integrates with Drupal directly on the DB layer, for maximum performance!
Q: I need to read/write X from/to my Drupal installation but there is no function in the Nodepal API for that.
A: Drupal has a huge API and it's not possible to replicate it in Node.js. Nodepal aims to grow organically, adding new functionality, depending on what I need for my projects or what its users request. You can always develop your own functionality using the current as template, or open a ticket and I'll try to add it.
As far as I know, LimitedList (http://limitedlist.com/) is using Drupal 6 + Nodepal + Node.js in production.
You can visit Nodepal's page on github to open tickets for feature requests or contribute :-)

Comments
How does this fit in with node.js integration?
See http://drupal.org/project/nodejs -
How do these two approaches compare to one another?
FunnyMonkey
Already tickted up :)
Saw this right after I posted.
http://drupal.org/node/1043830
FunnyMonkey