My fancy homebrew + dnsmasq & virtual host custom mamp localdev didn't make it past my upgrade to Mavericks... not wanting to go back to MAMP I decided it was time to learn how to use Vagrant. I'm liking it! It's basically a wrapper for vmware or virtual box that makes it handy to spin up isolated local test environments that you can create and destroy at will.
Two useful Drupal related projects:
https://github.com/dotless-de/vagrant-vbguest is handy if you're using virtualbox
https://drupal.org/project/drupal-up is useful but the boxes aren't well maintained. http://drupalcode.org/project/drupal-up.git/blob_plain/HEAD:/README.md
https://github.com/mikebell/drupaldev-nginx is something I haven't tested yet, but might be a better start than drupal-up