optimization

I am curious to know if anyone has advice on tweaking the out-of-the-box my.cnf specifically for Drupal?

The organization I work for typically hosts multisite installations, and may have numerous disparate sites running on a single web server using a single MySQL server... Given that there is a wide range of sites with varying purposes (some more anonymous viewing, some more authenticated content generation), are there any Drupal-specific changes to my.cnf which might be appropriate?